Dr. Johnson’s research is focused on the nano-scaled transport properties (charge, energy, spin, etc.) of nanostructures and single molecules, including carbon nanotubes, graphene, DNA, synthetic proteins, and other biomolecules. They are particularly interested in the physical properties of hybrid nanostructures and their use in molecular sensing. Other research interests include the development of scanning probe techniques for electronic property measurement of nanomaterials and nanodevices.
Johnson’s group webpage is: http://www.lrsm.upenn.edu/~nanophys/
1Cellular Organization and Signaling, National Centre for Biological Sciences, TIFR, Bangalore 560065, Karnataka, IndiaReceived Youth Jarome Iginla Jersey 3 November 2008; Revised 5 January 2009; Accepted 6 February 2009; Published online 6 March 2009. Top of pageAbstractThe Elite Red Miikka Kiprusoff Jersey regulation of cellular metabolism and survival by trophic factors is not completely understood. Here, we Authenitc Rasmus Andersson Jersey describe a signaling cascade activated by the developmental regulator Notch, which inhibits apoptosis triggered by neglect in mammalian cells. In this pathway, the Notch intracellular domain (NIC), which is released after interaction with ligand, converges on the kinase mammalian target of rapamycin (mTOR) and the substrate defining protein rapamycin independent companion of mTOR (Rictor), culminating in the activation of the kinase Akt Biochemical and molecular approaches using site directed mutants identified AktS473 as a key downstream target in the antiapoptotic pathway activated by NIC. Despite the demonstrated requirement for Notch processing
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